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Article

Role of asymmetric dimethylarginine for angiotensin II-induced target organ damage in mice.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2008

Jacobi Johannes, Maas Renke, Cordasic Nada, Koch Kilian, Schmieder Roland E, Böger Rainer H, Hilgers Karl F

Abstract excerpt

The aim of the present study was to investigate the role of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) and its degrading enzyme dimethylarginine dimethylaminohydrolase (DDAH) in angiotensin II (ANG II)-induced hypertension and target organ damage in mice. Mice transgenic for the human DDAH1 gene (TG) and wild-type (WT) mice (each, n = 28) were treated with 1.0 microg kg(-1)...

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Source

Identifiers

PMID: 18156199
DOI: 10.1152/ajpheart.01103.2007

Genes

ANG
DDAH1
DDAH2
PRMT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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