Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Iron genes, iron load and risk of Alzheimer’s disease

1 Oct 2006

Abstract excerpt

BACKGROUND: Compound heterozygotes of the haemochromatosis gene (HFE) variants, H63D and C282Y, have raised transferrin saturation compared with that in the wild type. In the cohort of the Oxford Project To Investigate Memory and Ageing (OPTIMA), bicarriers of the HFE C282Y and the transferrin C2 gene variants are at five times greater risk of developing Alzheimer's disease; the addition of HFE H63D may raise the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hemoglobinopathies and Related Disorders
Share to Intracerebral and Subarachnoid Hemorrhage Research
Share to Iron Metabolism and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17047092
DOI: 10.1136/jmg.2006.040519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Iron genes, iron load and risk of Alzheimer’s diseasePMID 17047092Read ↗

Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease.Semantic proximity Read ↗

HFE mutations and Alzheimer's diseaseSemantic proximity Read ↗

HFE gene variants, iron, and lipids: a novel connection in Alzheimerâ€™s diseaseSemantic proximity Read ↗

Prevalent iron metabolism gene variants associated with increased brain ferritin iron in healthy older men.Semantic proximity Read ↗

Gene-gene interactions among coding genes of iron-homeostasis proteins and APOE-alleles in cognitive impairment diseases.Semantic proximity Read ↗

Effects of hemochromatosis and transferrin gene mutations on peripheral iron dyshomeostasis in mild cognitive impairment and Alzheimer's and Parkinson's diseasesSemantic proximity Read ↗

Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort.Semantic proximity Read ↗

Effects of hemochromatosis and transferrin gene mutations on iron dyshomeostasis, liver dysfunction and on the risk of Alzheimer's disease.Semantic proximity Read ↗

HFE Genotype and Neurodegeneration: An Updated Systematic Review and Structured Evidence Synthesis with Four-Stratum ArchitectureSemantic proximity Read ↗

Haemochromatosis Genotypes and Incident Dementia in a Prospective Study of Older Adults.Semantic proximity Read ↗

Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesisSemantic proximity Read ↗

Genes related to iron metabolism and susceptibility to Alzheimer's disease in Basque population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.