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Article

Haemochromatosis Genotypes and Incident Dementia in a Prospective Study of Older Adults.

Neurology - 24 Jun 2025

Yu Chenglong, Delatycki Martin, Hussain Sultana Monira, McNeil John James, Lacaze Paul, Olynyk John K

Abstract excerpt

BACKGROUND AND OBJECTIVES: Variants in the homeostatic iron regulator (HFE) gene are prevalent among individuals of European ancestry and have been linked to an increased risk of dementia. This study aimed to evaluate the effects of HFE p.Cys282Tyr and p.His63Asp variants on serum ferritin levels and the incidence of dementia in a cohort of initially healthy older adults. METHOD: This prospective longitudinal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40440589
DOI: 10.1212/WNL.0000000000213743
PMCID: PMC12123751

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Haemochromatosis Genotypes and Incident Dementia in a Prospective Study of Older Adults.PMID 40440589Read ↗

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