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Article

A hemochromatosis allele that protects against Alzheimer's disease injury: A role for H-ferritin.

Journal of Alzheimer's disease : JAD - 1 Feb 2026

Rogers Jack T, Tsurumi Amy, Arai Ken, Wang Changning, Cahill Catherine M

Abstract excerpt

Recent epidemiological evidence showed that mutations to the HFE-63 allele of this hemochromatosis-associated iron-assimilation protein improve chances of avoiding Alzheimer's disease (AD). This is unexpected since increased brain ferroptosis in gray-matter increases the risk for vascular dementia and AD. However, diffusion tensor imaging from a key Alzheimer's Disease Neuroimaging Initiative biomarker study...

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Identifiers

PMID: 41428473
DOI: 10.1177/13872877251404974

Genes

HFE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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