Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort.

Journal of Alzheimer's disease : JAD - 1 Jan 2021

Atkins Janice L, Pilling Luke C, Heales Christine J, Savage Sharon, Kuo Chia-Ling, Kuchel George A, Steffens David C, Melzer David

Abstract excerpt

BACKGROUND: Brain iron deposition occurs in dementia. In European ancestry populations, the HFE p.C282Y variant can cause iron overload and hemochromatosis, mostly in homozygous males. OBJECTIVE: To estimate p.C282Y associations with brain MRI features plus incident dementia diagnoses during follow-up in a large community cohort. METHODS: UK Biobank participants with follow-up hospitalization records (mean 10.5...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Chemistry
Share to Databases as Topic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dementia

Share to Hemochromatosis

Share to Hemochromatosis Protein

Share to Neuroimaging

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 33427739
DOI: 10.3233/JAD-201080
PMCID: PMC7990419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort.PMID 33427739Read ↗

Haemochromatosis Genotypes and Incident Dementia in a Prospective Study of Older Adults.Semantic proximity Read ↗

HFE genotypes, haemochromatosis diagnosis and clinical outcomes at age 80 years: a prospective cohort study in the UK Biobank.Semantic proximity Read ↗

Genetic Risk for Hemochromatosis is Associated with Movement DisordersSemantic proximity Read ↗

Association of Genetic Variant Linked to Hemochromatosis With Brain Magnetic Resonance Imaging Measures of Iron and Movement Disorders.Semantic proximity Read ↗

Iron and risk of dementia: Mendelian randomisation analysis in UK BiobankSemantic proximity Read ↗

<i>HFE</i>genotypes, haemochromatosis diagnosis and clinical outcomes to age 80: a prospective cohort study in UK BiobankSemantic proximity Read ↗

Prevalent iron metabolism gene variants associated with increased brain ferritin iron in healthy older men.Semantic proximity Read ↗

Whole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals.Semantic proximity Read ↗

Genetic and lifestyle modifiers of haemochromatosis-related clinical outcomes in HFE C282Y homozygotes: prospective cohort study in UK BiobankSemantic proximity Read ↗

Predictors of brain iron deposition in dementia and Parkinson’s disease-associated subcortical regions: genetic and observational analysis in UK BiobankSemantic proximity Read ↗

HFE Genotype and Neurodegeneration: An Updated Systematic Review and Structured Evidence Synthesis with Four-Stratum ArchitectureSemantic proximity Read ↗

Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analysesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.