Article

<i>ketu</i> mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2

2017-08-06

Abstract excerpt

Mechanisms regulating mammalian meiotic progression are poorly understood. Here we identify mouse YTHDC2 as a critical component. A screen yielded a sterile mutant, “ ketu ”, caused by a Ythdc2 missense mutation. Mutant germ cells enter meiosis but proceed prematurely to aberrant metaphase and apoptosis, and display defects in transitioning from spermatogonial to meiotic gene expression programs. ketu phenocopi...

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Literature Corpus work: 58661a5e-4dd6-5280-aa3e-d6fb0ccaaeb1
DOI: 10.1101/171827

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