Article

The QxxR Motif of RNA Helicase Me31B Is Essential for Drosophila Female Fertility and Germline Development

2026-08-29

Abstract excerpt

The QxxR motif is evolutionarily conserved within DEAD-box RNA helicases, including Drosophila Me31B and human DDX6, which post-transcriptionally regulate gene expression during animal development. A pathogenic H372R substitution (Qx H R to Qx R R) in the QxxR motif of human DDX6 has been associated with various developmental defects, but how this motif contributes to DDX6-family protein function remains unclea...

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Literature Corpus work: 865134e9-1c20-5c00-b67a-b72a50937076
DOI: 10.64898/2026.08.27.747641

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