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Article

The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence.

Molecular cell - 21 Sept 2017

Ivanova Ivayla, Much Christian, Di Giacomo Monica, Azzi Chiara, Morgan Marcos, Moreira Pedro N, Monahan Jack, Carrieri Claudia, Enright Anton J, O'Carroll Dónal

Abstract excerpt

YTHDF2 binds and destabilizes N6-methyladenosine (m6A)-modified mRNA. The extent to which this branch of m6A RNA-regulatory pathway functions in vivo and contributes to mammalian development remains unknown. Here we find that YTHDF2 deficiency is partially permissive in mice and results in female-specific infertility. Using conditional mutagenesis, we demonstrate that YTHDF2 is autonomously required within the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28867294
DOI: 10.1016/j.molcel.2017.08.003
PMCID: PMC5613143

Genes

YTHDF2

Provenance

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Related research

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The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence.PMID 28867294Read ↗

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