Article
Human YTHDC2 mutations disturb RNA homeostasis of oocytes and early embryos.
Human genetics - 21 Mar 2026
Su Wei, Wang Yang, Sun Jiaqi, Zhang Changlong, Yin Changjian, Cui Ying, Chen Xiaolei, Yang Bohan, Zhao Shigang, Wu Keliang, Lin Ge, Chen Zi-Jiang, Zheng Wei, Zhang Honghui, Zhao Han
Abstract excerpt
Oocyte and early embryo competence defects (OECD) are a kind of Mendelian genetic disorder. While numerous pathogenic variants have been identified, the underlying molecular mechanisms remain largely elusive. In this study, through whole-exome sequencing of infertile patients, we identified five novel biallelic mutations in YTHDC2, a locus previously implicated in primary ovarian insufficiency, in four families...
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