Article

YTHDC2 serves a distinct late role in spermatocytes during germ cell differentiation

2023-01-23

Abstract excerpt

<h4>ABSTRACT</h4> Post-transcriptional regulation of gene expression by RNA-binding proteins can enhance the speed and robustness of cell state transitions by controlling RNA stability, localization, or if, when or where mRNAs are translated. The RNA helicase YTHDC2 is required to shut down components of the mitotic program to facilitate a proper switch from mitosis to meiosis in mouse germ cells. Here we show th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1dd2f6e-ba81-5eb5-ab00-285c0e671bff
DOI: 10.1101/2023.01.23.525146

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

YTHDC2 serves a distinct late role in spermatocytes during germ cell differentiationDOI 10.1101/2023.01.23.525146Read

YTHDF2 is essential for spermatogenesis and fertility through mediating a wave of transcript transition during spermatogonial differentiationSemantic proximity Read

<i>ketu</i> mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2Semantic proximity Read

Single-Cell RNA-seq Uncovers Dynamic Processes Orchestrated by RNA-Binding Protein DDX43 in Chromatin Remodeling during SpermiogenesisSemantic proximity Read

Chromatoid body integrates piRNA, SMG6 and m⁶A pathways to control mRNAs in the male germlineSemantic proximity Read

Single-Cell RNA-seq Uncovers Dynamic Processes Orchestrated by RNA-Binding Protein DDX43 in Chromatin Remodeling during SpermiogenesisSemantic proximity Read

A cell-type-specific multi-protein complex regulates expression of Cyclin B protein in <i>Drosophila</i> male meiotic prophaseSemantic proximity Read

SMG6 localizes to the chromatoid body and shapes the male germ cell transcriptome to drive spermatogenesisSemantic proximity Read

KDM6A/UTX promotes spermatogenic gene expression across generations but is dispensable for male fertilitySemantic proximity Read

DMRT proteins and coordination of mammalian spermatogenesisSemantic proximity Read

DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogoniaSemantic proximity Read

The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesisSemantic proximity Read

Single cell RNA sequencing reveals the landscape of early female germ cell developmentSemantic proximity Read