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Article

Identification of polycystin-1 and Gα12 binding regions necessary for regulation of apoptosis.

Cellular signalling - 1 Jan 2011

Yu Wanfeng, Ritchie Benjamin J, Su Xuefeng, Zhou Jing, Meigs Thomas E, Denker Bradley M

Abstract excerpt

Most patients with autosomal dominant polycystic kidney disease (ADPKD) harbor mutations in PKD1, the gene for polycystin-1 (PC1), a transmembrane protein with a cytoplasmic C-terminus that interacts with numerous signaling molecules, including Gα12. The functions of PC1 and the mechanisms of cyst development leading to renal failure are complex. Recently, we reported that PC1 expression levels modulate activity...

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Identifiers

PMID: 20837139
DOI: 10.1016/j.cellsig.2010.09.005
PMCID: PMC2998059

Genes

PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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