Article
A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development.
Nature cell biology - 1 Dec 2005
Kamiya Atsushi, Kubo Ken-ichiro, Tomoda Toshifumi, Takaki Manabu, Youn Richard, Ozeki Yuji, Sawamura Naoya, Park Una, Kudo Chikako, Okawa Masako, Ross Christopher A, Hatten Mary E, Nakajima Kazunori, Sawa Akira
Abstract excerpt
Disrupted-In-Schizophrenia-1 (DISC1), originally identified at the breakpoint of a chromosomal translocation that is linked to a rare familial schizophrenia, has been genetically implicated in schizophrenia in other populations. Schizophrenia involves subtle cytoarchitectural abnormalities that arise during neurodevelopment, but the underlying molecular mechanisms are unclear. Here, we demonstrate that DISC1 is a...
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