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Article

Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways.

Human molecular genetics - 15 Jul 2017

Shao Lisha, Lu Binyan, Wen Zhexing, Teng Shaolei, Wang Lingling, Zhao Yi, Wang Liyuan, Ishizuka Koko, Xu Xiufeng, Sawa Akira, Song Hongjun, Ming Guoli, Zhong Yi

Abstract excerpt

Although the genetic contribution is under debate, biological studies in multiple mouse models have suggested that the Disrupted-in-Schizophrenia-1 (DISC1) protein may contribute to susceptibility to psychiatric disorders. In the present study, we took the advantages of the Drosophila model to dissect the molecular pathways that can be affected by DISC1 in the context of pathology-related phenotypes. We found...

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Identifiers

PMID: 28472294
DOI: 10.1093/hmg/ddx147
PMCID: PMC5886174

Genes

DISC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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