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Novel GABAAR antagonists target networked gene hubs at the leading edge in high-grade gliomas

10 Jun 2025

Abstract excerpt

BACKGROUND: Ion channel activity underlying biological processes that drive high-grade gliomas (HGG) is largely unknown. We aimed to determine the networking of ion channel genes and validate their expression within HGG patient tumors, to identify ion channel-targeting drugs that would inhibit tumor-promoting processes. METHODS: We used weighted gene co-expression network analysis (WGCNA) of RNAseq data to...

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Share to Glioma Diagnosis and Treatment
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PMID: 40497637
DOI: 10.1093/neuonc/noaf143

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