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Article

Plasma Membrane TRPV4 Relocalization as a Mechanosensitive Prognostic Biomarker in Ductal Carcinoma In Situ

2025-11-05

Abstract excerpt

<h4>Purpose</h4> Reliable prediction of invasive progression remains an unmet need in ductal carcinoma in situ (DCIS). Conventional histologic grading provides limited prognostic value. Building on mechanistic evidence that cell crowding in confined ducts engages a TRPV4-dependent mechanotransduction program, we evaluated plasma-membrane TRPV4 (PM-TRPV4) relocalization as a mechanosensitive, patient-level prognos...

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Literature Corpus work
43cb264a-7dc3-5abf-b499-b5aa764aba3b
DOI
10.1101/2025.11.04.25339245
Open publication

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