Article

Digital Spatial Pathway Mapping Reveals Prognostic Tumor States in Head and Neck Cancer

2025-11-26

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is a morphologically and molecularly heterogeneous disease with limited effectiveness of genotype-informed therapies. Transcriptome-derived estimates of signaling pathway activity carry prognostic and therapeutic potential but remain inaccessible in routine diagnostics due to cost and tissue constraints. Here, we introduce Digital Spatial Pathway Mapping , an AI-based...

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Literature Corpus work: 3d4304fb-4569-5e40-84e2-e92f23ccc7ee
DOI: 10.1101/2025.11.24.689710

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