Article

Context-dependent correlations mislead transcriptomic network inference in bulk and single-cell data

2026-06-29

Abstract excerpt

<h4>Background</h4> Correlation is the dominant input to co-expression module discovery and miRNA-target inference. Both rely on an implicit assumption: a Pearson coefficient pooled across heterogeneous samples, whether tissues, cancer types, or cell types, estimates one biologically meaningful quantity. Simpson’s paradox makes this assumption fragile in principle, since between- group mean shifts can dominate or...

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Literature Corpus work: 3e4350c5-3ebc-5bfd-b1d7-5cf61ebfcef7
DOI: 10.64898/2026.06.23.733936

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