Article

Restoration of <i>Sp4</i> in forebrain GABAergic neurons rescues hypersensitivity to ketamine in <i>Sp4</i> hypomorphic mice

2015-02-26

Abstract excerpt

Ketamine produces schizophrenia-like behavioral phenotypes in healthy people. Prolonged ketamine effects and exacerbation of symptoms were observed in schizophrenia patients after administration of ketamine. More recently, ketamine has been used as a potent antidepressant to treat patients with major depression. The genes and neurons that regulate behavioral responses to ketamine, however, remain poorly understood...

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Literature Corpus work: 57dff116-9f10-5da8-944a-cf21cec0ad1b
DOI: 10.1101/015677

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