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Article

Prolonged Ketamine Effects in Sp4 Hypomorphic Mice: Mimicking Phenotypes of Schizophrenia.

PloS one - 1 Jan 2013

Ji Baohu, Wang Xin, Pinto-Duarte Antonio, Kim Minjung, Caldwell Sorana, Young Jared W, Behrens Margarita M, Sejnowski Terrence J, Geyer Mark A, Zhou Xianjin

Abstract excerpt

It has been well established that schizophrenia patients display impaired NMDA receptor (NMDAR) functions as well as exacerbation of symptoms in response to NMDAR antagonists. Abnormal NMDAR signaling presumably contributes to cognitive deficits which substantially contribute to functional disability in schizophrenia. Establishing a mouse genetic model will help investigate molecular mechanisms of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23823008
DOI: 10.1371/journal.pone.0066327
PMCID: PMC3688895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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