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Article

Pharmacological modulation of AMPA receptors rescues specific impairments in social behavior associated with the A350V Iqsec2 mutation.

Translational psychiatry - 22 Apr 2021

Jabarin Renad, Levy Nina, Abergel Yasmin, Berman Joshua H, Zag Amir, Netser Shai, Levy Andrew P, Wagner Shlomo

Abstract excerpt

In this study we tested the hypothesis that pharmacological modulation of glutamatergic neurotransmission could rescue behavioral deficits exhibited by mice carrying a specific mutation in the Iqsec2 gene. The IQSEC2 protein plays a key role in glutamatergic synapses and mutations in the IQSEC2 gene are a frequent cause of neurodevelopmental disorders. We have recently reported on the molecular pathophysiology of...

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Identifiers

PMID: 33888678
DOI: 10.1038/s41398-021-01347-1
PMCID: PMC8062516

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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