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Article

Partial rescue of schizophrenia-related phenotypes in young adult Sp4 hypomorphic mice.

Journal of psychiatric research - 1 Jul 2025

Kamp Joris, Sikkink Megan E, Buell Mahalah R, Powell Susan B, Zhou Xianjin

Abstract excerpt

The Schizophrenia Exome Sequencing Meta-Analysis (SCHEMA) Consortium found that truncation of one copy of the SP4 gene has an odds ratio of 9.37 (3.38-29.7) for schizophrenia (SCZ). Human SP4 gene is also one of the 69 schizophrenia-risk genes prioritized by parallel genome-wide association studies (GWAS) and one of the two schizophrenia-risk genes shared between the SCHEMA and the GWAS, suggesting that more...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40339225
DOI: 10.1016/j.jpsychires.2025.05.002
PMCID: PMC12560505

Genes

SP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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