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Article

Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes.

Nature neuroscience - 1 Jan 2010

Belforte Juan E, Zsiros Veronika, Sklar Elyse R, Jiang Zhihong, Yu Gu, Li Yuqing, Quinlan Elizabeth M, Nakazawa Kazu

Abstract excerpt

Cortical GABAergic dysfunction may underlie the pathophysiology of psychiatric disorders, including schizophrenia. Here, we characterized a mouse strain in which the essential NR1 subunit of the NMDA receptor (NMDAR) was selectively eliminated in 40-50% of cortical and hippocampal interneurons in...

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Identifiers

PMID: 19915563
DOI: 10.1038/nn.2447
PMCID: PMC2797836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19915563-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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