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Article

Transcription factor SP4 is a susceptibility gene for bipolar disorder.

PloS one - 1 Jan 2009

Zhou Xianjin, Tang Wei, Greenwood Tiffany A, Guo Shengzhen, He Lin, Geyer Mark A, Kelsoe John R

Abstract excerpt

The Sp4 transcription factor plays a critical role for both development and function of mouse hippocampus. Reduced expression of the mouse Sp4 gene results in a variety of behavioral abnormalities relevant to human psychiatric disorders. The human SP4 gene is therefore examined for its association with both bipolar disorder and schizophrenia in European Caucasian and Chinese populations respectively. Out of ten...

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Identifiers

PMID: 19401786
DOI: 10.1371/journal.pone.0005196
PMCID: PMC2674320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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