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JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells

20 Aug 2008

Abstract excerpt

Cytokines contribute to pancreatic beta-cell apoptosis in type 1 diabetes (T1D) by modulation of beta-cell gene expression networks. The transcription factor Activator Protein-1 (AP-1) is a key regulator of inflammation and apoptosis. We presently evaluated the function of the AP-1 subunit JunB in cytokine-mediated beta-cell dysfunction and death. The cytokines IL-1beta+IFN-gamma induced an early and transitory...

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PMID: 18716665
DOI: 10.1371/journal.pone.0003030

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