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Article

Domain-selective targeting of BET proteins in cancer and immunological diseases

30 Jul 2020

Abstract excerpt

Cancer and inflammation are strongly interconnected processes. Chronic inflammatory pathologies can be at the heart of tumor development; similarly, tumor-elicited inflammation is a consequence of many cancers. The mechanistic interdependence between cancer and inflammatory pathologies points toward common protein effectors which represent potential shared targets for pharmacological intervention. Epigenetic...

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PMID: 32741705
DOI: 10.1016/j.cbpa.2020.02.003

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