Article

FXR and BET signaling orchestrate to protect β cells

2026-04-14

Abstract excerpt

In both type 1 and type 2 diabetes (T1D and T2D), insulin-producing β cells undergo progressive dysfunction due to inflammation, leading to impaired glucose responsiveness, dedifferentiation, and cell loss. While bile acid (BA) dysregulation under diabetic conditions is known to influence metabolic and inflammatory pathways, its mechanistic role in β cell regulation remains incompletely defined 1–3 . Here we show...

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Literature Corpus work: 646340e2-b36c-5745-b99b-2892f07ad361
DOI: 10.64898/2026.04.10.716420

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