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SKEMPI 2.0: an updated benchmark of changes in protein-protein binding energy, kinetics and thermodynamics upon mutation.

Bioinformatics (Oxford, England) - 1 Feb 2019

Jankauskaite Justina, Jiménez-García Brian, Dapkunas Justas, Fernández-Recio Juan, Moal Iain H

Abstract excerpt

Motivation: Understanding the relationship between the sequence, structure, binding energy, binding kinetics and binding thermodynamics of protein-protein interactions is crucial to understanding cellular signaling, the assembly and regulation of molecular complexes, the mechanisms through which mutations lead to disease, and protein engineering. Results: We present SKEMPI 2.0, a major update to our database of...

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Identifiers

PMID: 30020414
DOI: 10.1093/bioinformatics/bty635
PMCID: PMC6361233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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