Article

PremPS: Predicting the Effects of Single Mutations on Protein Stability

2020-04-07

Abstract excerpt

<h4>ABSTRACT</h4> Protein stability is related to its functional activities, and effect on stability or misfolding could be one of the major disease-causing mechanisms of missense mutations. Here we developed a novel machine learning computational method PremPS, which predicts the effects of single mutations on protein stability by calculating the changes in unfolding Gibbs free energy. PremPS uses only ten evolu...

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Literature Corpus work: aaf9a373-9dad-56ce-af5f-41a3507ad17a
DOI: 10.1101/2020.04.07.029074

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