Article

Further Development of SAMPDI-3D: Machine Learning Method for Predicting Binding Free Energy Changes Caused by Mutations in Either Protein or DNA

2024-12-30

Abstract excerpt

<h4>Background: </h4> /Objectives: Predicting the effects of mutations in proteins and DNA on the binding free energy of protein-DNA complexes is crucial for understanding how DNA variants impact wild-type cellular function. As many cellular interactions involve protein-DNA binding, accurately predicting changes in binding free energy (ΔΔG) is valuable for distinguishing pathogenic mutations from benig...

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Literature Corpus work: 984cda55-0382-5c20-adcb-d343e152380b
DOI: 10.20944/preprints202412.2430.v1

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