Article

MechPPI: Binding Mechanism-based Machine-Learning tool for Predicting Protein-Protein Binding Affinity Changes Upon Mutations

2023-10-31

Abstract excerpt

Protein-protein interactions are essential for various biological processes, including signal transduction, metabolism, vesicle transport, and mitogenic processes. It’s crucial to consider them within the context of their interactions with other proteins to understand protein function. Mutations in proteins can affect their binding affinity to partner proteins by introducing various effects, such as changes in hyd...

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Literature Corpus work: 5280d980-0b37-5ccb-80a6-330b3d75d378
DOI: 10.1101/2023.10.26.564257

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