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Mitochondrial DNA-triggered innate immune response: mechanisms and diseases

7 Nov 2023

Abstract excerpt

Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from mitochondria into the cytosol. The released mtDNA is sensed by the cGAS-MITA/STING pathway, resulting in the induced expression of type I interferon and other effector genes. These processes contribute to the innate immune response to viral infection and other stress factors. The deregulation of these processes causes autoimmune...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37932533
DOI: 10.1038/s41423-023-01086-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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