Article

Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in mice

2022-02-04

Abstract excerpt

The innate immune system can protect against certain aspects of neurodegenerative diseases, but also contribute to disease progression. Stimulator of interferon genes (STING) is activated after detection of cytoplasmic dsDNA by cGAS (cyclic GMP-AMP synthase) as part of the defense against viral pathogens, activating type I interferon and NF-kB/inflammasome signaling. In order to specifically test the relevance of...

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Literature Corpus work: 4f6af16b-3c90-5b9d-916e-422274978714
DOI: 10.1101/2022.02.02.478854

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