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Mitophagy and cGAS–STING crosstalk in neuroinflammation

13 May 2024

Abstract excerpt

Mitophagy, essential for mitochondrial health, selectively degrades damaged mitochondria. It is intricately linked to the cGAS-STING pathway, which is crucial for innate immunity. This pathway responds to mitochondrial DNA and is associated with cellular stress response. Our review explores the molecular details and regulatory mechanisms of mitophagy and the cGAS-STING pathway. We critically evaluate the...

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Autophagy in Disease and Therapy
Inflammasome and immune disorders
interferon and immune responses

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39220869
DOI: 10.1016/j.apsb.2024.05.012

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