Article

IFI204 Drives Gasdermin D–Mediated Mitochondrial Permeabilization to Amplify Neuronal Pyroptosis in Ischemic Stroke

2026-01-23

Abstract excerpt

<title>Abstract</title> <p>Gasdermin D (GSDMD)–mediated pore formation on mitochondrial membranes is known to exacerbate pyroptosis. The cytosolic DNA sensor interferon activated gene 204 (IFI204) can activate the inflammasome to induce pyroptosis. However, whether and how IFI204 regulates mitochondrial membrane permeabilization to drive pathological outcomes in ischemic stroke remains unclear. Here, using a mous...

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Literature Corpus work: 33909461-b456-5750-9b6e-17b5e641dc4b
DOI: 10.21203/rs.3.rs-8641308/v1

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