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Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia

13 Mar 2024

Abstract excerpt

The stimulator of interferon genes (STING) pathway has been implicated in neurodegenerative diseases, including Parkinson's disease and amyotrophic lateral sclerosis (ALS). While prior studies have focused on STING within immune cells, little is known about STING within neurons. Here, we document neuronal activation of the STING pathway in human postmortem cortical and spinal motor neurons from individuals...

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PMID: 38478117
DOI: 10.1007/s00401-024-02688-z

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