Article

Titin as a mechanical damper: Balancing Stability and longevity through inter-domain linker design

2025-03-06

Abstract excerpt

Titin, a giant protein (∼3-4 MDa), functions as a molecular-spring to regulate muscle elasticity. More than 90% of Titin is composed of domains that absorb mechanical energy and undergo stochastic unfolding-refolding under tension (∼tens of pN). These domains are connected in tandem by interdomain linkers (IDLs), which constitute less than 10% of the total mass. Despite their small genomic footprint, bioinformatic...

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Literature Corpus work: 57c36a63-31c4-5a3f-990d-86217b878c0c
DOI: 10.1101/2025.03.03.641210

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