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Article

Hidden complexity in the mechanical properties of titin.

Nature - 27 Mar 2003

Williams Philip M, Fowler Susan B, Best Robert B, Toca-Herrera José Luis, Scott Kathryn A, Steward Annette, Clarke Jane

Abstract excerpt

Individual molecules of the giant protein titin span the A-bands and I-bands that make up striated muscle. The I-band region of titin is responsible for passive elasticity in such muscle, and contains tandem arrays of immunoglobulin domains. One such domain (I27) has been investigated extensively, using dynamic force spectroscopy and simulation. However, the relevance of these studies to the behaviour of the...

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Identifiers

PMID: 12660787
DOI: 10.1038/nature01517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hidden complexity in the mechanical properties of titin.PMID 12660787Read ↗

The Y9P Variant of the Titin I27 Module: Structural Determinants of Its Revisited Nanomechanics.Semantic proximity Read ↗

Mechanical stability and differentially conserved physical-chemical properties of titin Ig-domains.Semantic proximity Read ↗

Structural basis for unfolding pathway-dependent stability of proteins: vectorial unfolding versus global unfolding.Semantic proximity Read ↗

Mechanical unfolding of a titin Ig domain: structure of transition state revealed by combining atomic force microscopy, protein engineering and molecular dynamics simulations.Semantic proximity Read ↗

The influence of disulfide bonds on the mechanical stability of proteins is context dependent.Semantic proximity Read ↗

Titin as a mechanical damper: Balancing Stability and longevity through inter-domain linker designSemantic proximity Read ↗

Structural diversity in the atomic resolution 3D fingerprint of the titin M-band segment.Semantic proximity Read ↗

Titins: Giant Proteins in Charge of Muscle Ultrastructure and ElasticitySemantic proximity Read ↗

Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complexSemantic proximity Read ↗

Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function.Semantic proximity Read ↗

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Two operational modes of atomic force microscopy reveal similar mechanical properties for homologous regions of dystrophin and utrophinSemantic proximity Read ↗

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