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Article

Linker Length and Composition within Disordered Binding Motifs Modulates the Avidity and Reversibility of a Multivalent Protein Interaction Switch.

Journal of molecular biology - 15 Dec 2025

Chatterjee Kiran Sankar, Martinez-Yamout Maria A, Dyson H Jane, Wright Peter E

Abstract excerpt

Intrinsically disordered proteins that mediate the cellular transcriptional response to hypoxia play important roles in regulating oxygen stress genes. The feedback inhibitor CITED2 operates a unidirectional switch that efficiently terminates the hypoxic response by displacing the C-terminal activation domain of the hypoxia-inducible factor HIF-1α from its complex with the TAZ1 domain of the transcriptional...

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Identifiers

PMID: 41015114
DOI: 10.1016/j.jmb.2025.169455
PMCID: PMC13160384

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CITED2

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