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Article

Dystrophin As a Molecular Shock Absorber

20 Nov 2018

Abstract excerpt

Dystrophin is the largest protein isoform (427 kDa) expressed from the gene defective in Duchenne muscular dystrophy, a lethal muscle-wasting and genetically inherited disease. Dystrophin, localized within a cytoplasmic lattice termed costameres, connects the intracellular cytoskeleton of a myofiber through the cell membrane (sarcolemma) to the surrounding extracellular matrix. In spite of its mechanical...

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PMID: 30457830
DOI: 10.1021/acsnano.8b05721

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