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Article

Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism.

Journal of molecular biology - 30 Apr 2021

Zhou Tiankun, Fleming Jennifer R, Lange Stephan, Hessel Anthony L, Bogomolovas Julius, Stronczek Chiara, Grundei David, Ghassemian Majid, Biju Andrea, Börgeson Emma, Bullard Belinda, Linke Wolfgang A, Chen Ju, Kovermann Michael, Mayans Olga

Abstract excerpt

Striated muscle responds to mechanical overload by rapidly up-regulating the expression of the cardiac ankyrin repeat protein, CARP, which then targets the sarcomere by binding to titin N2A in the I-band region. To date, the role of this interaction in the stress response of muscle remains poorly understood. Here, we characterise the molecular structure of the CARP-receptor site in titin (UN2A) and its binding of...

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Identifiers

PMID: 33647290
DOI: 10.1016/j.jmb.2021.166901
PMCID: PMC8052292

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