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Article

Lesion search and recognition by thymine DNA glycosylase revealed by single molecule imaging.

Nucleic acids research - 11 Mar 2015

Buechner Claudia N, Maiti Atanu, Drohat Alexander C, Tessmer Ingrid

Abstract excerpt

The ability of DNA glycosylases to rapidly and efficiently detect lesions among a vast excess of nondamaged DNA bases is vitally important in base excision repair (BER). Here, we use single molecule imaging by atomic force microscopy (AFM) supported by a 2-aminopurine fluorescence base flipping assay to study damage search by human thymine DNA glycosylase (hTDG), which initiates BER of mutagenic and cytotoxic G:T...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25712093
DOI: 10.1093/nar/gkv139
PMCID: PMC4357730

Genes

AFM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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