Back to search

Article

Non-autonomous PMK-1/p38 MAPK signaling ensures homeostatic downregulation of germline stem cell proliferation in <i>C. elegans</i>

2025-09-25

Abstract excerpt

<h4>Summary</h4> Stem cell underproliferation leads to tissue loss while over proliferation favors hyperplasia and tumorigenesis. Stem and progenitor proliferation rates are therefore usually coupled to the needs for their differentiated cellular progenies in the tissue(s) they serve. We used the C. elegans hermaphrodite reproductive system to understand how germline stem cell (GSC) proliferation is linked to sp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4d424e3e-a1f3-5fc5-bd6d-7525348a4fc9
DOI
10.1101/2025.09.24.678176
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Non-autonomous PMK-1/p38 MAPK signaling ensures homeostatic downregulation of germline stem cell proliferation in <i>C. elegans</i>DOI 10.1101/2025.09.24.678176
<i>mab-2</i>encodes RNT-1, a<i>C. elegans</i>Runx homologue essential for controlling cell proliferation in a stem cell-like developmental lineageSemantic proximity
<i>Caenorhabditis elegans</i> as a model for stem cell biologySemantic proximity
C. elegans germline stem cells and their nicheSemantic proximity
The Ras-ERK MAPK regulatory network controls dedifferentiation in Caenorhabditis elegans germline.Semantic proximity
Non-autonomy of age-related morphological changes in the C. elegans germline stem cell niche.Semantic proximity
Controls of Germline Stem Cells, Entry into Meiosis, and the Sperm/Oocyte Decision in<i>Caenorhabditis elegans</i>Semantic proximity
Genetic and Chemical Controls of Sperm Fate and Spermatocyte Dedifferentiation in <em>Caenorhabditis elegans</em>Semantic proximity
C. elegans germ cells divide and differentiate in a folded tissueSemantic proximity
Cell cycle features of C. elegans germline stem/progenitor cells vary temporally and spatially.Semantic proximity
A Phenotype-Based RNAi Screening for Ras-ERK/MAPK Signaling-Associated Stem Cell Regulators in C. elegans.Semantic proximity
Soma‐germline interactions that influence germline proliferation in <i>Caenorhabditis elegans</i>Semantic proximity
A Genome-Wide RNAi Screen for Enhancers of a Germline Tumor Phenotype Caused by Elevated GLP-1/Notch Signaling in Caenorhabditis elegans.Semantic proximity
Select a neighboring publication to make it the new centre.