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Article

Reduction of Derlin activity suppresses Notch-dependent tumours in the C. elegans germ line.

PLoS genetics - 1 Sept 2021

Singh Ramya, Smit Ryan B, Wang Xin, Wang Chris, Racher Hilary, Hansen Dave

Abstract excerpt

Regulating the balance between self-renewal (proliferation) and differentiation is key to the long-term functioning of all stem cell pools. In the Caenorhabditis elegans germline, the primary signal controlling this balance is the conserved Notch signaling pathway. Gain-of-function mutations in the GLP-1/Notch receptor cause increased stem cell self-renewal, resulting in a tumour of proliferating germline stem...

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Identifiers

PMID: 34555015
DOI: 10.1371/journal.pgen.1009687
PMCID: PMC8491880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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