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Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons

7 Sept 2016

Abstract excerpt

Cell-fate reprograming is at the heart of development, yet very little is known about the molecular mechanisms promoting or inhibiting reprograming in intact organisms. In the C. elegans germline, reprograming germ cells into somatic cells requires chromatin perturbation. Here, we describe that such reprograming is facilitated by GLP-1/Notch signaling pathway. This is surprising, since this pathway is best known...

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PMID: 27602485
DOI: 10.7554/elife.15477

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