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Article

The Bro1-domain protein, EGO-2, promotes Notch signaling in Caenorhabditis elegans.

Genetics - 1 Aug 2007

Liu Ying, Maine Eleanor M

Abstract excerpt

In Caenorhabditis elegans, as in other animals, Notch-type signaling mediates numerous inductive events during development. The mechanism of Notch-type signaling involves proteolytic cleavage of the receptor and subsequent transport of the receptor intracellular domain to the nucleus, where it acts as a transcriptional regulator. Notch-type signaling activity is modulated by post-translational modifications and...

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Identifiers

PMID: 17603118
DOI: 10.1534/genetics.107.071225
PMCID: PMC1950630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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