Article

CRC genome-driven metabolic reprogramming and immune microenvironment remodeling

2024-04-03

Abstract excerpt

<title>Abstract</title> <p>Background Colorectal cancer is a global digestive tract malignancy closely tied to microsatellite instability (MSI). MSI stems from DNA mismatch repair issues, categorized as MSI-High (MSI-H), MSI-Low (MSI-L), or Stable (MSS). Tailoring treatments based on MSI status is vital. MSI-H tumors, with high mutation and neoantigen loads, respond well to immune checkpoint inhibitors (ICIs). H...

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Literature Corpus work: 5794b67a-a243-51cf-b5ec-f886ce3fca74
DOI: 10.21203/rs.3.rs-4090131/v1

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