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Article

The Landscape of Alterations in DNA Damage Response Pathways in Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2021

Arai Hiroyuki, Elliott Andrew, Xiu Joanne, Wang Jingyuan, Battaglin Francesca, Kawanishi Natsuko, Soni Shivani, Zhang Wu, Millstein Joshua, Sohal Davendra, Goldberg Richard M, Hall Michael J, Scott Aaron J, Khushman Moh'd, Hwang Jimmy J, Lou Emil, Weinberg Benjamin A, Marshall John L, Lockhart Albert C, Stafford Phillip, Zhang Jian, Moretto Roberto, Cremolini Chiara, Korn W Michael, Lenz Heinz-Josef

Abstract excerpt

PURPOSE: Defective DNA damage response (DDR) is a hallmark of cancer leading to genomic instability and is associated with chemosensitivity. Although the mismatch repair system has been extensively studied, the clinical implications of other mechanisms associated with DDR alterations in patients with colorectal cancer remain unclear. This study aimed to understand DDR pathways alterations and their association...

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Colorectal Cancer Treatments and Studies
Colorectal Neoplasms
DNA Damage
Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic factors in colorectal cancer

Genomic Instability

Microsatellite Instability

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Identifiers

PMID: 33766816
DOI: 10.1158/1078-0432.CCR-20-3635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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