Article

Reduced Filaggrin expression induces dysregulated intracellular signalling in atopic eczema

2024-03-12

Abstract excerpt

Atopic eczema (AE) is the most common inflammatory dermatosis, affecting up to 20% of children. Loss of function mutations in the Filaggrin ( FLG ) gene are the most strongly implicated genetic risk factor for AE, but little is known about the signalling pathways altered in response to loss of FLG. To explore the downstream effects of loss of FLG on the cellular environment, we combined RNAseq analysis of siRNA...

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Literature Corpus work: 577859db-357e-54cf-be9c-23de6f6cc011
DOI: 10.1101/2024.03.11.584344

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