Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

28 May 2014

Abstract excerpt

BACKGROUND: Atopic dermatitis (AD; eczema) is characterized by a widespread abnormality in cutaneous barrier function and propensity to inflammation. Filaggrin is a multifunctional protein and plays a key role in skin barrier formation. Loss-of-function mutations in the gene encoding filaggrin (FLG) are a highly significant risk factor for atopic disease, but the molecular mechanisms leading to dermatitis remain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dermatology and Skin Diseases
Share to Drug-Induced Adverse Reactions
Share to Psoriasis: Treatment and Pathogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24880632
DOI: 10.1016/j.jaci.2014.04.021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitisPMID 24880632Read ↗

Genetics of Atopic Dermatitis: From DNA Sequence to Clinical RelevanceSemantic proximity Read ↗

Exome Sequencing of Filaggrin and Related Genes in African-American Children with Atopic DermatitisSemantic proximity Read ↗

Filaggrin loss-of-function variants are associated with atopic dermatitis phenotypes in a diverse, early-life prospective cohort.Semantic proximity Read ↗

Trying to understand the genetics of atopic dermatitis.Semantic proximity Read ↗

Integrating multi‐omics approaches in deciphering atopic dermatitis pathogenesis and future therapeutic directionsSemantic proximity Read ↗

Tiled array-based sequencing identifies enrichment of loss-of-function variants in the highly homologous filaggrin gene in African-American children with severe atopic dermatitis.Semantic proximity Read ↗

Enhanced Expression of Genes Related to Xenobiotic Metabolism in the Skin of Patients with Atopic Dermatitis but Not with Ichthyosis VulgarisSemantic proximity Read ↗

Filaggrin and beyondSemantic proximity Read ↗

An update on the genetics of atopic dermatitis: scratching the surface in 2009.Semantic proximity Read ↗

Comprehensive Transcriptomic Analysis of Atopic Dermatitis Patients Documents the Spectrum of Molecular Abnormalities and the Response to TreatmentSemantic proximity Read ↗

RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implicationsSemantic proximity Read ↗

Influence of FLG loss-of-function mutations in host-microbe interactions during atopic skin inflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.