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Article

In a three-dimensional reconstructed human epidermis filaggrin-2 is essential for proper cornification

19 Feb 2015

Abstract excerpt

Atopic dermatitis is a chronic inflammatory skin disease with defects in the epidermal barrier. In a cohort of African-American children, a FLG2 nonsense mutation has been associated with the disease. In the epidermis of European patients, the expression of filaggrin-2, the filaggrin-related protein encoded by FLG2, is decreased. To describe the function of filaggrin-2 and evaluate the impact of its deficiency,...

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PMID: 25695608
DOI: 10.1038/cddis.2015.29

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